PF-06840003 coglurant I-BRD9 is the first selective

I-BRD9 is the first selective tool compound available to elucidate the cellular phenotype of BRD9 bromodomain inhibition

Epub 2016 May 31

Dolastatin 15 induces apoptosis of myeloma cells via activation of both mitochondrial- and Fas (CD95)/Fas-L (CD95-L)-mediated pathways

A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells

CAS Number: 1355026-60-6

PF-06840003 coglurant I-BRD9 is the first selectivePF 06840003 (EOS200271) is a highly selective orally bioavailable IDO 1 inhibitor with IC50s of 0. 41 M, 0. 59 M, and 1. 5 M for hIDO 1, dIDO 1, and mIDO 1, respectively. Product information CAS Number: 198474 05 4 Molecular Weight: 232. 21 Formula: C12H9FN2O2 Chemical Name: 3 (5 fluoro 1H indol 3 yl)pyrrolidine 2,5 dione Smiles: O=C1NC(=O)CC1C1=CNC2C=CC(F)=CC1=2 InChiKey: MXKLDYKORJEOPR UHFFFAOYSA N InChi: InChI=1S C12H9FN2O2 c13 6 1 2 10 7(3 6)9(5